Biomarker vaj huam sib luag kwv yees ntshav qab zib thaum cev xeeb tub

Biomarker vaj huam sib luag kwv yees ntshav qab zib thaum cev xeeb tub
Biomarker vaj huam sib luag kwv yees ntshav qab zib thaum cev xeeb tub
Anonim

Cov kws tshawb fawb los ntawm University of California, Los Angeles (UCLA) tau ua thawj kauj ruam hauv kev txheeb xyuas txoj hauv kev zoo txhawm rau kuaj ntshav qab zib gestational diabetes mellitus (GDM) thaum lub sijhawm cev xeeb tub.

Kev txheeb xyuas cov biomarkers ntawm GD thaum cev xeeb tub yuav ua rau muaj kev saib xyuas zoo dua thiab txhim kho kev nyab xeeb thiab raws sijhawm thiab kev kho mob uas yuav txo cov kab mob, yog li txhim kho kev noj qab haus huv mus sij hawm ntev rau niam thiab cov xeeb ntxwv.

Rau lawv txoj kev tshawb fawb, cov kws tshawb fawb tau tsom mus rau cov hlwv extracellular (EVs) - circulating "communicators" uas nqa thiab xa cov noob microRNA (miRNAs) mus rau hauv niam cov ntshav. Lawv tau zais los ntawm cov placenta thiab ua lub luag haujlwm tseem ceeb hauv kev xeeb tub thiab kev xeeb tub, suav nrog GD.

Cov kws tshawb fawb tau kuaj ntshav hauv txhua lub peb hlis ntuj thiab thaum yug me nyuam rau miRNA qhia hauv EVs hauv 24 tus poj niam cev xeeb tub. Lawv pom tias muaj qhov sib txawv miRNA qhia hauv EVs cais los ntawm thawj peb lub hlis twg cov ntshav kuaj los ntawm cov poj niam uas thaum kawg kuaj pom GD piv rau cov uas cev xeeb tub.

Tus kws sau ntawv sau tseg cov kev hloov pauv hauv cov miRNAs ua ntej kev kuaj mob.

Qhov no qhia tau tias lawv tau koom nrog kev txhim kho tus kabmob thiab tsis yog vim muaj cov xwm txheej thib ob ntawm tus kabmob nws tus kheej lossis kev kho mob xws li insulin, uas tuaj yeem cuam tshuam rau cov ntsiab lus ntawm miRNA hauv kev ncig EVs.

Cov kws tshawb fawb tseem pom cov kev cai hauv qee cov miRNAs hauv thawj peb lub hlis twg cov poj niam cev xeeb tub uas tau kuaj pom GD tom qab. Raws li cov kws tshawb fawb, qhov no qhia ntxiv tias miRNA cargo nyob rau hauv EVs circulating EVs yuav sib txuas lus nrog rau lwm leej niam lub cev nqaij daim tawv thiab cell hom, thiab cuam tshuam nrog cov teeb liab txoj kev koom tes nyob rau hauv cov metabolism thiab o, uas yuav cuam tshuam rau leej niam metabolic adaptations pom nyob rau hauv cov poj niam. GZD.

Gestational diabetes paub tias yuav ua rau cov ntshav qab zib ntau ntxiv ntawm cov poj niam cev xeeb tub, tsim kev pheej hmoo rau tus menyuam thiab leej niam. Qhov no tuaj yeem ua rau muaj ntshav siab, muaj feem yuav mob ntshav qab zib tom ntej, thiab muaj feem ntau ntawm C-section rau leej niam, nrog rau qhov hnyav thaum yug, yug ntxov ntxov, thiab lwm yam teeb meem rau nws tus menyuam.

Kev kuaj mob ntawm tus mob tam sim no yog nyob ntawm kev tshuaj ntsuam ib txwm thiab kev ua haujlwm hauv chaw kuaj mob tom qab cev xeeb tub. Muaj peev xwm kwv yees tus mob ua ntej yog ib qho ntawm cov yuam sij kom txo nws qhov cuam tshuam.

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