Copper refreshes cov ntshav thiab tiv thaiv Alzheimer's

Cov txheej txheem:

Copper refreshes cov ntshav thiab tiv thaiv Alzheimer's
Copper refreshes cov ntshav thiab tiv thaiv Alzheimer's
Anonim

Kev tswj hwm ntawm cov ntaub so ntswg tooj liab ua lub luag haujlwm tseem ceeb hauv ntau yam kab mob, suav nrog Alzheimer's kab mob, Parkinson's thiab lub cev muaj zog neurosis

Kev tshawb fawb txog cov molecules uas muab tooj liab rau cov ntshav muab lub qab ntug tshiab rau kev kuaj mob thiab kev kho mob, ceeb toom Medicalnewstoday.com.

tooj liab yog qhov tseem ceeb rau cov metabolism hauv ib txwm. Tab sis cov kws tshawb fawb paub me ntsis xav tsis thoob txog tias lub cev thauj nws li cas thiab nws tswj cov ntaub so ntswg zoo li cas. Cuam tshuam rau cov protein molecules, tooj liab yog qhov tseem ceeb ntawm ntau cov enzymes uas ua rau cov tshuaj tiv thaiv metabolic tseem ceeb.

"Biochemists tau ntev tau paub txog qhov tseem ceeb ntawm tooj liab hauv tib neeg lub cev, tab sis txawm lawv tsis paub tias lub caij no tau txais los ntawm peb cov zaub mov mus rau qhov chaw tsim nyog, piv txwv li.e. ntau yam tooj liab enzymes,"hais Prof. Peep Puluma, tus thawj coj ntawm Metalloproteins Research Group ntawm Tallinn University of Technology hauv Estonia.

Cov tooj liab ntau tshaj plaws muaj nyob hauv daim siab, hlwb, lub plawv, ob lub raum thiab cov leeg pob txha.

Lub luag haujlwm tseem ceeb

Cov hlau tooj liab yog qhov tseem ceeb rau kev tsim hluav taws xob thaum lub sijhawm ua pa ntawm tes, tsim cov qe ntshav liab, tiv thaiv kab mob, thiab kev saib xyuas cov paj hlwb. Yog tias ntau dhau, nws tuaj yeem ua rau tsim cov dawb radicals puas tsuaj thiab ua rau mob hauv lub cev. Kev tshawb fawb qhia tau hais tias cov teeb meem tswj cov qib tooj liab tau pom hauv cov kab mob neurodegenerative, suav nrog Menkes syndrome, kab mob neuron lub cev muaj zog, Parkinson's disease thiab Alzheimer's disease.

A 2013 txoj kev tshawb fawb pom tias thaum tooj liab sib sau hauv lub hlwb, nws txhawb kev loj hlob ntawm beta-amyloid plaques, uas yog cov cim ntawm Alzheimer's disease. Biochemists tau nrhiav kom nkag siab zoo txog yuav ua li cas lub cev tswj tau qhov zoo ntawm tooj liab hauv nws cov ntaub so ntswg thiab yuav ua li cas tshwm sim thaum cov txheej txheem homeostatic cuam tshuam.

Kev paub tuaj yeem pab lawv tsim txoj hauv kev tshiab los kuaj xyuas, saib xyuas thiab kho cov kab mob. Raws li ib feem ntawm qhov kev siv zog no, Prof Puluma thiab nws cov npoj yaig xav nkag siab tias tooj liab thauj mus los ntawm lub cev ntawm cov ntshav li cas. Kev npaj txhij txog, lawv pom tias cov txheej txheem tsis nyuaj. Biochemists yav dhau los xav tias peb cov proteins ua lub luag haujlwm hauv kev thauj mus los ntawm tooj liab. Tab sis raws li kev tshawb fawb tshiab, tsuas yog ib tus ntawm lawv yog tus neeg ua si loj.

Kev sib haum xeeb rau tooj liab

ntsuas txhua cov protein ntawm tooj liab affinity, lub ntsiab lus nruj npaum li cas nws khi rau tooj liab ions, cov kws tshawb fawb tau tsim ib txoj hauv kev tshiab thiab tshiab hu ua kua chromatography thiab ICP-MS (inductively coupled plasma mass spectrometry).

Cov txheej txheem biochemical no cais thiab txheeb xyuas cov molecules uas muaj nyob rau hauv cov kua roj ntsha xws li ntshav lossis cov kua cerebrospinal. Cov kws tshawb fawb pom tau tias hauv cov ntshav, kwv yees li 75% ntawm tooj liab ions raug khi rau enzyme ceruloplasmin, thaum txog 25% yog khi rau enzyme albumin. Txawm li cas los xij, ceruloplasmin khi rau tooj liab kom nruj kom nws tsis zoo li ua lub luag haujlwm hauv kev thauj cov hlau mus rau qhov chaw uas nws xav tau. Lub luag haujlwm tseem ceeb ntawm cov enzyme zoo li yog los pab lwm cov protein thauj - hlau hauv cov ntshav.

Ntawm qhov tod tes, albumin khi rau tooj liab tsawg dua thiab tej zaum yog lub ntsiab tooj liab thauj khoom. Cov kws tshawb nrhiav pom tias qee qhov me me ntawm tooj liab hauv cov ntshav (kwv yees li 0.2%) kuj khi rau cov amino acid histidine.

Histidine tau xav tias ua lub luag haujlwm rau kev tso cov tooj liab los ntawm albumin thaum nws mus txog, piv txwv li, lub siab. Biochemists ntseeg tias lwm cov protein hu ua alpha-2 macroglobulin kuj thauj tooj liab. Txawm li cas los xij, tus xibfwb thiab nws cov npoj yaig tau tshaj tawm tias hauv lawv qhov kev sim, cov protein no tsis khi rau tooj liab hauv cov ntshav plasma ntau npaum li cas.

Regulating tooj liab

Prof. Puluma thiab nws cov npoj yaig hais tias lawv qhov kev tshawb pom tuaj yeem ua rau nws muaj peev xwm txheeb xyuas qhov cuam tshuam ntawm cov metabolism hauv tooj liab uas ua rau cov kab mob xws li Alzheimer's. Lawv txoj kev tshawb fawb kuj tseem yuav muab txoj hauv kev tshiab los saib xyuas cov tshuaj muaj txiaj ntsig los tswj cov qib tooj liab.

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